IGF-1

FDA Approved

Also known as: Insulin-like Growth Factor 1, Mecasermin, Increlex, Somatomedin C

Prescription Only — FDA Approved Medication

Educational Content Only

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. The FDA has not evaluated many of the peptides discussed here. Always consult a licensed healthcare provider before making any health decisions.

Overview

IGF-1 (insulin-like growth factor 1) is an endogenous polypeptide hormone critical for growth, development, and metabolic homeostasis. It is produced primarily in the liver in response to GH signaling and acts through IGF-1 receptors on virtually all tissues. Recombinant IGF-1 (mecasermin) is FDA-approved for children with severe primary IGF-1 deficiency.

Possible Uses

The following areas have been examined in research contexts. This does not constitute medical advice or imply proven efficacy in humans.

Muscle Recovery & Repair
Growth Hormone Regulation
Fat Loss & Metabolism

Mechanism of Action

Activates IGF-1 receptors (IGF1R), a receptor tyrosine kinase, triggering PI3K/Akt/mTOR and MAPK signaling cascades that promote cell growth, protein synthesis, glucose uptake, and inhibit apoptosis. Mediates many of the anabolic and growth-promoting effects of growth hormone.

Safety Notes

FDA-approved (Increlex/mecasermin) for severe primary IGF-1 deficiency in pediatric patients. Risks include hypoglycemia, intracranial hypertension, and potential growth-promoting effects on existing neoplasms. Off-label use not FDA-sanctioned.

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Research Profile

Half-Life

~12-15 minutes (free form); much longer when bound to IGFBPs

Administration

subcutaneous injection

Legal Status (US)

FDA-approved prescription medication for specific pediatric indications. Off-label injectable use is a research chemical. Banned by WADA.

32 indexed research passages

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