Tadalafil

FDA Approved

Also known as: Cialis, Adcirca, Alyq

Prescription Only — FDA Approved Medication

Educational Content Only

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. The FDA has not evaluated many of the peptides discussed here. Always consult a licensed healthcare provider before making any health decisions.

Overview

Tadalafil is an FDA-approved phosphodiesterase type 5 (PDE5) inhibitor used clinically for erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. It is distinguished among PDE5 inhibitors by its long duration of action, with effects studied for up to 36 hours.

Possible Uses

The following areas have been examined in research contexts. This does not constitute medical advice or imply proven efficacy in humans.

Sexual Function
Cardiovascular Health

Mechanism of Action

Inhibits PDE5, the enzyme responsible for degrading cyclic GMP (cGMP) in smooth muscle. Elevated cGMP levels promote smooth muscle relaxation and vasodilation in the corpus cavernosum and pulmonary vasculature, facilitating physiological responses.

Safety Notes

FDA-approved. Contraindicated with nitrates due to severe hypotension risk. Common side effects include headache, flushing, dyspepsia, and myalgia. Caution in cardiovascular disease.

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Research Profile

Half-Life

~17.5 hours

Administration

oral tablet

Legal Status (US)

FDA-approved prescription medication (Cialis for ED/BPH, Adcirca/Alyq for PAH).

250 indexed research passages

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